Frontiers in Nephrology: Tolerance
نویسندگان
چکیده
منابع مشابه
Frontiers in nephrology: tolerance.
The field of transplantation has come a long way since the first successful kidney transplant performed by Murray and colleagues in 1954. Kidney, heart, lung, and liver transplantation, among other organs, is now routine, and short-term (1 yr) outcomes have steadily improved to rates of 90 to 95% graft survival (http://www.unos.org). Despite these successes, the major shortfall of our current t...
متن کاملFrontiers in nephrology: immune tolerance to allografts in humans.
Vascularized allografts are rejected unless some indefinite modification to the recipient's immune system is made. This modification is typically achieved through the long-term administration of immunosuppressive drugs. Patients thus trade their end-stage organ failure for dependence on daily drug therapy and the accompanying chronic condition of immunodeficiency. However, it is clear from stud...
متن کاملFRONTIERS IN NEPHROLOGY Inherited Distal Renal Tubular Acidosis
Renal acid-base balance may become deranged in a number of ways, some of which are the consequence of inherited disorders. Two main groups of distal renal acidopathies result either from a direct inability to secrete acid in the distal nephron (giving rise to type 1 renal tubular acidosis [RTA]) or as an inherited or functional consequence of hypoaldosteronism, leading to type 4 (hyperkalemic) ...
متن کاملFRONTIERS IN NEPHROLOGY Renal Tubular Acidosis: The Clinical Entity
The term renal tubular acidosis (RTA) is applied to a group of transport defects in the reabsorption of bicarbonate (HCO3 ), the excretion of hydrogen ion (H ), or both. This condition was first described in 1935 (1), confirmed as a renal tubular disorder in 1946 (2), and designated “renal tubular acidosis” in 1951 (3). The RTA syndromes are characterized by a relatively normal GFR and a metabo...
متن کاملFrontiers in nephrology: early atherosclerosis--a view beyond the lumen.
Endothelial dysfunction is an established clinical marker of early coronary artery disease and has been shown to be associated with increased cardiovascular morbidity and mortality. New concepts now extend the view of endothelial dysfunction beyond the traditional involvement of the coronary arterial endothelium alone. Recent research indicates that the coronary vessel wall, especially the vasa...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2007
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2007050560